Biological role of phlorotannis extracted from brown algae and its activity in the diabetic treatment: Thesis Abstract

Thesis Abstract Diabetes mellitus characterized by hyperglycemia which associated with failure of various organs. Therefore, this study aims to investigate biological activity including the antioxidant, antibacterial and antidiabetic activities polyphenolic compound phlorotannis derived from Egyptian brown seaweed Cystoseira compressa Sargassum linifolium. Phlorotannis has been extracted confirmed different chemical physical tests. The extracts exhibited higher antioxidant properties. Phlorotannis showed evaluated against species [Staphylococcus aureus, Escherichia coli, Bacillus cereus]. In vivo fifty white male albino rats were divided into six equal groups. first three groups are control normal, C. extract S. linifolium groups, last diabetic intraperitoneal injection streptozotocin (STZ) had one that got 60 mg/kg after four weeks diabetes induction. decrease serum glucose, α-amylase, glucosidase liver malondialdehyde (MDA). However insulin, hepatic glutathione total capacityTAC significantly increased compared non-treated Also make activation AMPKα2 expression in skeletal muscle treated group as group. histopathological results supported markedly reduce damage β cells pancreas. Finally algae have capacity act agents. These point phlorotannins potential pharmaceutical resources for human health.